Genome Evolution Course – 2009-2010

Evolution by Genome Duplication

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Presentation: PPT or PDF

Essay version

Topics

• Susumu Ohno and evolution by gene duplication
• The Drosophila genome
• Homeotic mutations
• Hox genes
• What is an animal?
• Genome Duplication during chordate evolution?
• Genome duplications happen(ed)
• The 2R hypothesis
• Methods of molecular archeology
• Map-based (spatial) – S. cerevisiae and Arabidopsis examples
• Tree-based (temporal)
• Recent progress suggests one genome duplication in vertebrate evolution.

Suggested readings

• Genome duplication in S. cerevisiae
• Proof (!) of genome duplication in S. cerevisiae
• Genome duplication in the vertebrate genome
• A review on genome duplications
• Genome duplications in a ciliate’s genome
• What is an animal: Slack et al. Nature 361 (1993), 490-492

Assignment

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Back to the Genome Evolution Course.

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Itai Yanai, yanai@technion.ac.il